Ontology highlight
ABSTRACT:
SUBMITTER: Sanchez-Sanz G
PROVIDER: S-EPMC5055338 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Sánchez-Sanz Goar G Tywoniuk Bartłomiej B Matallanas David D Romano David D Nguyen Lan K LK Kholodenko Boris N BN Rosta Edina E Kolch Walter W Buchete Nicolae-Viorel NV
PLoS computational biology 20161007 10
RASSF enzymes act as key apoptosis activators and tumor suppressors, being downregulated in many human cancers, although their exact regulatory roles remain unknown. A key downstream event in the RASSF pathway is the regulation of MST kinases, which are main effectors of RASSF-induced apoptosis. The regulation of MST1/2 includes both homo- and heterodimerization, mediated by helical SARAH domains, though the underlying molecular interaction mechanism is unclear. Here, we study the interactions b ...[more]