Domain-mediated interactions for protein subfamily identification.
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ABSTRACT:
SUBMITTER: Lee H
PROVIDER: S-EPMC6959277 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Publications
Domain-mediated interactions for protein subfamily identification.
Lee Heetak H Kim Inhae I Han Seong Kyu SK Kim Donghyo D Kong Jungho J Kim Sanguk S
Scientific reports 20200114 1
Within a protein family, proteins with the same domain often exhibit different cellular functions, despite the shared evolutionary history and molecular function of the domain. We hypothesized that domain-mediated interactions (DMIs) may categorize a protein family into subfamilies because the diversified functions of a single domain often depend on interacting partners of domains. Here we systematically identified DMI subfamilies, in which proteins share domains with DMI partners, as well as wi ...[more]
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