Ontology highlight
ABSTRACT:
SUBMITTER: Chen G
PROVIDER: S-EPMC5055443 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Chen Guangyu G Shu Hao H Chen Gang G Ward B Douglas BD Antuono Piero G PG Zhang Zhijun Z Li Shi-Jiang SJ
Journal of Alzheimer's disease : JAD 20161001 3
This study aims to develop a composite biomarker that can accurately measure the sequential biological stages of Alzheimer's disease (AD) on an individual level. We selected 144 subjects from the Alzheimer's Disease Neuroimaging Initiative 2 datasets. Ten biomarkers, from brain function and structure, cerebrospinal fluid, and cognitive performance, were integrated using the event-based probabilistic model to estimate their optimal temporal sequence (Soptimal). We identified the numerical order o ...[more]