Ontology highlight
ABSTRACT:
SUBMITTER: Dekker AD
PROVIDER: S-EPMC5384293 | biostudies-other | 2017
REPOSITORIES: biostudies-other
Dekker Alain D AD Fortea Juan J Blesa Rafael R De Deyn Peter P PP
Alzheimer's & dementia (Amsterdam, Netherlands) 20170320
Down syndrome (DS), present in nearly six million people, is associated with an extremely high risk to develop Alzheimer's disease (AD). Amyloid-β and tau pathology are omnipresent from age 40 years onward, but clinical symptoms do not appear in all DS individuals. Dementia diagnostics is complex in this population, illustrating the great need for predictive biomarkers. Although blood biomarkers have not yet proven useful, cerebrospinal fluid (CSF) biomarkers (low amyloid-β42, high t-tau, and hi ...[more]