Dataset Information

Association between ELMO1 gene polymorphisms and diabetic nephropathy in an Iranian population.

ABSTRACT: BACKGROUND:Diabetic nephropathy (DN) is one of the leading causes of death in patients with type 2 diabetes mellitus (T2DM). Several genome-wide association studies have introduced ?Engulfment and Cell Motility 1 (ELMO1) ?as a candidate gene which is associated with DN. This study assessed the association of ELMO1 gene polymorphisms with DN in order to investigate the effects of ELMO1 gene on susceptibility to DN in an Iranian population. METHODS:In the present study, 100 patients with T2DM, 100 patients with DN and 100 healthy subjects who were matched for sex were selected. Allele and genotype frequencies were determined by Tetra-ARMS PCR technique. In all groups, levels of FBS, creatinine, urea, HbA1C, urine levels of albumin creatinine ratio and glomerular filtration rate were measured. RESULTS:A statistically significant association was shown between G allele of rs741301 (odds ratio (OR)?=?1.7 [95 % CI 1.17-2.63]; p value?=?0.005), and GG genotypes of rs741301 (OR?=?2.5 [95 % CI 1.2-5.4]; p value?=?0.01) and DN. A significant association was not detected between allelic and genotypic frequencies of rs1345365 and DN. Linkage Disequilibrium (LD) between two variants was weak (D'?=?0.11, r2?=?0.008). rs1345365A/rs741301A haplotypes were more frequent in patients with T2DM as compared to DN (OR?=?0.5 [95 % CI 0.3-0.7]; p value?=?0.0006). Also, genotypes of variant rs741301 in all subjects had significant difference with respect to the mean of ACR (p Value?

SUBMITTER: Mehrabzadeh M

PROVIDER: S-EPMC5055690 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Association between ELMO1 gene polymorphisms and diabetic nephropathy in an Iranian population.

Mehrabzadeh Mohsen M Pasalar Parvin P Karimi Mostafa M Abdollahi Maryam M Daneshpour Maryam M Asadolahpour Effat E Razi Farideh F

Journal of diabetes and metabolic disorders 20150101

<h4>Background</h4>Diabetic nephropathy (DN) is one of the leading causes of death in patients with type 2 diabetes mellitus (T2DM). Several genome-wide association studies have introduced Engulfment and Cell Motility 1 (ELMO1) as a candidate gene which is associated with DN. This study assessed the association of ELMO1 gene polymorphisms with DN in order to investigate the effects of ELMO1 gene on susceptibility to DN in an Iranian population.<h4>Methods</h4>In the present study, 100 patients ...[more]

PMID: 27761430

Similar Datasets

Project description:BackgroundTumor necrosis factor-alpha (TNF-α) is an important cytokine in acute inflammatory response to infective factors. Based on investigation in different populations, it is thought that this response increases in patients with endometriosis due to the presence of cytokines such as TNF-α. This study aimed to examine the association of four TNF-α polymorphisms, namely -238G/A, -308G/A, -857C/T and -863C/A, with susceptibility to endometriosis in an Iranian population.Materials and methodsWe recruited 150 women with endometriosis and 150 women without endometriosis in this case-control study and collected 4 ml of blood from all subjects. After DNA extraction, the polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).ResultsThe allele frequency of TNF-α -863C/A in the case and control groups showed a significant difference [odds ratios (OR)=0.64, 95% confidence interval (CI)=0.41-0.99, P=0.047] but the result is not significant when Adjusting for multiple testing (P=0.188). No significant difference in the allele frequencies of -238G/A (OR=1.07, 95% CI=0.51-2.25, P=0.862), -308G/A (OR=0.79, 95% CI=0.43-1.45, P=0.438) and -857C/T (OR=1.03, 95% CI=0.66- 1.61, P=0.887) was observed. We adjusted all four polymorphism genotypes by age and body mass index (BMI), however, no significant difference was detected. There was an association between the case and control and BMI when adjusting by age (OR=1.082, 95% CI=1.009-1.162, P=0.028).ConclusionFor the first time the association of the four polymorphisms in the promoter region of the TNF-α gene with endometriosis has been conducted in women of Iranian origin. The present research reveals the -863 A allele may play a role in incidence of endometriosis among Iranian women. Development of endometriosis among those people with -863 A allele seems low. According to the results, the current study indicates that there might be a correlation between BMI and progression of endometriosis.

Dataset Information

Association between ELMO1 gene polymorphisms and diabetic nephropathy in an Iranian population.

Publications

Association between ELMO1 gene polymorphisms and diabetic nephropathy in an Iranian population.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets