Ontology highlight
ABSTRACT:
SUBMITTER: Peng D
PROVIDER: S-EPMC3980983 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
BioMed research international 20140323
<h4>Objective</h4>Toll-like receptor 4 (TLR4) plays a central role in innate immunity. Activation of innate immune response and subsequent chronic low-grade inflammation are thought to be involved in the pathogenesis of diabetic nephropathy. In this study, we aimed to investigate whether TLR4 variants are associated with diabetic nephropathy in the Chinese population.<h4>Methods</h4>Seven tagging single nucleotide polymorphisms (SNPs) of TLR4 based on HapMap Chinese data were genotyped in 1,455 ...[more]