Ontology highlight
ABSTRACT:
SUBMITTER: Buckley CM
PROVIDER: S-EPMC5056073 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Buckley Catherine M CM Gopaldass Navin N Bosmani Cristina C Johnston Simon A SA Soldati Thierry T Insall Robert H RH King Jason S JS
Proceedings of the National Academy of Sciences of the United States of America 20160919 40
Macropinocytosis is an ancient mechanism that allows cells to harvest nutrients from extracellular media, which also allows immune cells to sample antigens from their surroundings. During macropinosome formation, bulk plasma membrane is internalized with all its integral proteins. It is vital for cells to salvage these proteins before degradation, but the mechanisms for sorting them are not known. Here we describe the evolutionarily conserved recruitment of the WASH (WASP and SCAR homolog) compl ...[more]