Ontology highlight
ABSTRACT:
SUBMITTER: Wattelet-Boyer V
PROVIDER: S-EPMC5056404 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Wattelet-Boyer Valérie V Brocard Lysiane L Jonsson Kristoffer K Esnay Nicolas N Joubès Jérôme J Domergue Frédéric F Mongrand Sébastien S Raikhel Natasha N Bhalerao Rishikesh P RP Moreau Patrick P Boutté Yohann Y
Nature communications 20160929
The post-Golgi compartment trans-Golgi Network (TGN) is a central hub divided into multiple subdomains hosting distinct trafficking pathways, including polar delivery to apical membrane. Lipids such as sphingolipids and sterols have been implicated in polar trafficking from the TGN but the underlying mechanisms linking lipid composition to functional polar sorting at TGN subdomains remain unknown. Here we demonstrate that sphingolipids with α-hydroxylated acyl-chains of at least 24 carbon atoms ...[more]