Ontology highlight
ABSTRACT:
SUBMITTER: Mazzitelli S
PROVIDER: S-EPMC5057504 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Mazzitelli Sonia S Filipello Fabia F Rasile Marco M Lauranzano Eliana E Starvaggi-Cucuzza Chiara C Tamborini Matteo M Pozzi Davide D Barajon Isabella I Giorgino Toni T Natalello Antonino A Matteoli Michela M
Acta neuropathologica communications 20161010 1
Substantial data indicate that amyloid-β (Aβ), the major component of senile plaques, plays a central role in Alzheimer's Disease and indeed the assembly of naturally occurring amyloid peptides into cytotoxic aggregates is linked to the disease pathogenesis. Although Aβ42 is a highly aggregating form of Aβ, the co-occurrence of shorter Aβ peptides might affect the aggregation potential of the Aβ pool. In this study we aimed to assess whether the structural behavior of human Aβ42 peptide inside t ...[more]