Ontology highlight
ABSTRACT:
SUBMITTER: Bansal S
PROVIDER: S-EPMC6645473 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Bansal Sunil S Maurya Indresh Kumar IK Yadav Nitin N Thota Chaitanya Kumar CK Kumar Vinod V Tikoo Kulbhushan K Chauhan Virander Singh VS Jain Rahul R
ACS omega 20180828 8
Since the introduction of acetyl cholinesterase inhibitors as the first approved drugs by the US Food and Drug Administration for Alzheimer's disease (AD) in clinics, less than satisfactory success in the design of anti-AD agents has impelled the scientists to also focus toward inhibition of Aβ aggregation. Considering the specific binding of fragments for their parent peptide, herein, we synthesized more than 40 new peptides based on a C-terminus tetrapeptide fragment of Aβ<sub>1-42</sub>. Init ...[more]