Ontology highlight
ABSTRACT:
SUBMITTER: Stevens H
PROVIDER: S-EPMC5058509 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Stevens Holly H Williams Ashley B AB Michael W Matthew WM
PloS one 20161011 10
To better understand how the cellular response to DNA replication stress is regulated during embryonic development, we and others have established the early C. elegans embryo as a model system to study this important problem. As is the case in most eukaryotic cell types, the replication stress response is controlled by the ATR kinase in early worm embryos. In this report we use RNAi to systematically characterize ATR pathway components for roles in promoting cell cycle delay during a replication ...[more]