Ontology highlight
ABSTRACT:
SUBMITTER: Fullenkamp CA
PROVIDER: S-EPMC5058666 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Fullenkamp Colleen A CA Hall Sarah L SL Jaber Omar I OI Pakalniskis Brittany L BL Savage Erica C EC Savage Johanna M JM Ofori-Amanfo Georgina K GK Lambertz Allyn M AM Ivins Stephanie D SD Stipp Christopher S CS Miller Benjamin J BJ Milhem Mohammed M MM Tanas Munir R MR
Oncotarget 20160501 21
TAZ (WWTR1) and YAP are transcriptional coactivators and oncoproteins inhibited by the Hippo pathway. Herein we evaluate 159 sarcomas representing the most prevalent sarcoma types by immunohistochemistry for expression and activation (nuclear localization) of TAZ and YAP. We show that 50% of sarcomas demonstrate activation of YAP while 66% of sarcomas demonstrate activated TAZ. Differential activation of TAZ and YAP are identified in various sarcoma types. At an RNA level, expression of WWTR1 or ...[more]