Ontology highlight
ABSTRACT:
SUBMITTER: Zak KM
PROVIDER: S-EPMC5058683 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Zak Krzysztof M KM Grudnik Przemyslaw P Guzik Katarzyna K Zieba Bartosz J BJ Musielak Bogdan B Dömling Alexander A Dubin Grzegorz G Holak Tad A TA
Oncotarget 20160501 21
Targeting the PD-1/PD-L1 immunologic checkpoint with monoclonal antibodies has provided unprecedented results in cancer treatment in the recent years. Development of chemical inhibitors for this pathway lags the antibody development because of insufficient structural information. The first nonpeptidic chemical inhibitors that target the PD-1/PD-L1 interaction have only been recently disclosed by Bristol-Myers Squibb. Here, we show that these small-molecule compounds bind directly to PD-L1 and th ...[more]