Ontology highlight
ABSTRACT:
SUBMITTER: Frigola J
PROVIDER: S-EPMC5058714 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Frigola Joan J Iturbide Ane A Lopez-Bigas Nuria N Peiro Sandra S Gonzalez-Perez Abel A
Oncotarget 20160501 21
Chromatin regulatory factors (CRFs), are known to be involved in tumorigenesis in several cancer types. Nevertheless, the molecular mechanisms through which driver alterations of CRFs cause tumorigenesis remain unknown. Here, we developed a CRFs Oncomodules Discovery approach, which mines several sources of cancer genomics and perturbaomics data. The approach prioritizes sets of genes significantly miss-regulated in primary tumors (oncomodules) bearing mutations of driver CRFs. We applied the ap ...[more]