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Integrative radiogenomic analysis for genomic signatures in glioblastomas presenting leptomeningeal dissemination.

ABSTRACT: Despite therapeutic advances, the prognosis for glioblastoma (GBM) remains poor. In particular, leptomeningeal dissemination (LMD) has a dismal prognosis. The aim of this study was to identify tumor molecular phenotype, which has a great propensity to develop LMD. Between May 2004 and December 2012, a total of 145 GBM tumor samples were obtained from data registry. A total of 20 of the 145 patients with GBM were found to develop LMD. A specialized radiologist confirmed the diagnosis of LMD on magnetic resonance imaging. To clarify the genomic signatures in GBM with LMD, we performed integrative analysis of whole transcriptome sequencing and copy number alteration in the radiological features indicating LMD phenotypes in GBM. Eleven newly diagnosed patients with GBM with LMD had worse prognosis than those without LMD (median 5.55 vs. 12.94 months, P?

SUBMITTER: You HJ

PROVIDER: S-EPMC5058842 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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Integrative radiogenomic analysis for genomic signatures in glioblastomas presenting leptomeningeal dissemination.

You Hye Jin HJ Park Ho-Young HY Kim Jinkuk J Lee In-Hee IH Seol Ho Jun HJ Lee Jung-Il JI Kim Sung Tae ST Kong Doo-Sik DS Nam Do-Hyun DH

Medicine 20160701 27

Despite therapeutic advances, the prognosis for glioblastoma (GBM) remains poor. In particular, leptomeningeal dissemination (LMD) has a dismal prognosis. The aim of this study was to identify tumor molecular phenotype, which has a great propensity to develop LMD. Between May 2004 and December 2012, a total of 145 GBM tumor samples were obtained from data registry. A total of 20 of the 145 patients with GBM were found to develop LMD. A specialized radiologist confirmed the diagnosis of LMD on ma ...[more]

PMID: 27399113

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