Divergent effects of central melanocortin signalling on fat and sucrose preference in humans.
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ABSTRACT:
SUBMITTER: van der Klaauw AA
PROVIDER: S-EPMC5059464 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Publications
Divergent effects of central melanocortin signalling on fat and sucrose preference in humans.
van der Klaauw Agatha A AA Keogh Julia M JM Henning Elana E Stephenson Cheryl C Kelway Sarah S Trowse Victoria M VM Subramanian Naresh N O'Rahilly Stephen S Fletcher Paul C PC Farooqi I Sadaf IS
Nature communications 20161004
Melanocortin-4-receptor (MC4R)-expressing neurons modulate food intake and preference in rodents but their role in human food preference is unknown. Here we show that compared with lean and weight-matched controls, MC4R deficient individuals exhibited a markedly increased preference for high fat, but a significantly reduced preference for high sucrose food. These effects mirror those in Mc4r null rodents and provide evidence for a central molecular circuit influencing human macronutrient prefere ...[more]
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