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Model simulation of the SPOC wave in a bundle of striated myofibrils.

ABSTRACT: SPOC (spontaneous oscillatory contraction) is a phenomenon observed in striated muscle under intermediate activation conditions. Recently, we constructed a theoretical model of SPOC for a sarcomere, a unit sarcomere model, which explains the behavior of SPOC at each sarcomere level. We also constructed a single myofibril model, which visco-elastically connects the unit model in series, and explains the behaviors of SPOC at the myofibril level. In the present study, to understand the SPOC properties in a bundle of myofibrils, we extended the single myofibril model to a two-dimensional (2D) model and a three-dimensional (3D) model, in which myofibrils were elastically connected side-by-side through cross-linkers between the Z-lines and M-lines. These 2D and 3D myofibril models could reproduce various patterns of SPOC waves experimentally observed in a 2D sheet and a 3D bundle of myofibrils only by choosing different values of elastic constants of the cross-linkers and the external spring. The results of these 2D and 3D myofibril models provide insight into the SPOC properties of the higher-ordered assembly of myofibrils.

SUBMITTER: Nakagome K

PROVIDER: S-EPMC5060095 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Model simulation of the SPOC wave in a bundle of striated myofibrils.

Nakagome Koutaro K Sato Katsuhiko K Shintani Seine A SA Ishiwata Shin'ichi S

Biophysics and physicobiology 20160927

SPOC (spontaneous oscillatory contraction) is a phenomenon observed in striated muscle under intermediate activation conditions. Recently, we constructed a theoretical model of SPOC for a sarcomere, <i>a unit sarcomere model</i>, which explains the behavior of SPOC at each sarcomere level. We also constructed <i>a single myofibril model</i>, which visco-elastically connects the unit model in series, and explains the behaviors of SPOC at the myofibril level. In the present study, to understand th ...[more]

PMID: 27924277

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Dataset Information

Model simulation of the SPOC wave in a bundle of striated myofibrils.

Publications

Model simulation of the SPOC wave in a bundle of striated myofibrils.

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