Ontology highlight
ABSTRACT:
SUBMITTER: Zhou B
PROVIDER: S-EPMC5061593 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Zhou Bo B Wang Jingya J Lee Shirley Y SY Xiong Jie J Bhanu Natarajan N Guo Qi Q Ma Peilin P Sun Yuqing Y Rao Rajesh C RC Garcia Benjamin A BA Hess Jay L JL Dou Yali Y
Molecular cell 20160414 2
PRDM16 is a transcription co-factor that plays critical roles in development of brown adipose tissue, as well as maintenance of adult hematopoietic and neural stem cells. Here we report that PRDM16 is a histone H3K4 methyltransferase on chromatin. Mutation in the N-terminal PR domain of PRDM16 abolishes the intrinsic enzymatic activity of PRDM16. We show that the methyltransferase activity of PRDM16 is required for specific suppression of MLL fusion protein-induced leukemogenesis both in vitro a ...[more]