Ontology highlight
ABSTRACT:
SUBMITTER: Yeom J
PROVIDER: S-EPMC5062161 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Yeom Jeonghun J Kabir Mohammad Humayun MH Lim Byungho B Ahn Hee-Sung HS Kim Seon-Young SY Lee Cheolju C
Scientific reports 20161013
Variations in protein coding sequence may sometimes play important roles in cancer development. However, since variants may not express into proteins due to various cellular quality control systems, it is important to get protein-level evidence of the genomic variations. We present a proteogenomic strategy getting protein-level evidence of genomic variants, which we call sequential targeted LC-MS/MS based on prediction of peptide pI and Retention time (STaLPIR). Our approach shows improved pepti ...[more]