Ontology highlight
ABSTRACT:
SUBMITTER: Trammell SA
PROVIDER: S-EPMC5062546 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Trammell Samuel A J SA Schmidt Mark S MS Weidemann Benjamin J BJ Redpath Philip P Jaksch Frank F Dellinger Ryan W RW Li Zhonggang Z Abel E Dale ED Migaud Marie E ME Brenner Charles C
Nature communications 20161010
Nicotinamide riboside (NR) is in wide use as an NAD<sup>+</sup> precursor vitamin. Here we determine the time and dose-dependent effects of NR on blood NAD<sup>+</sup> metabolism in humans. We report that human blood NAD<sup>+</sup> can rise as much as 2.7-fold with a single oral dose of NR in a pilot study of one individual, and that oral NR elevates mouse hepatic NAD<sup>+</sup> with distinct and superior pharmacokinetics to those of nicotinic acid and nicotinamide. We further show that single ...[more]