Ontology highlight
ABSTRACT:
SUBMITTER: Stojkovic V
PROVIDER: S-EPMC5062987 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Stojković Vanja V Noda-Garcia Lianet L Tawfik Dan S DS Fujimori Danica Galonić DG
Nucleic acids research 20160805 18
Modifications of the bacterial ribosome regulate the function of the ribosome and modulate its susceptibility to antibiotics. By modifying a highly conserved adenosine A2503 in 23S rRNA, methylating enzyme Cfr confers resistance to a range of ribosome-targeting antibiotics. The same adenosine is also methylated by RlmN, an enzyme widely distributed among bacteria. While RlmN modifies C2, Cfr modifies the C8 position of A2503. Shared nucleotide substrate and phylogenetic relationship between RlmN ...[more]