Ontology highlight
ABSTRACT: Purpose
To compare three commonly used retinal vessel caliber measurement software systems, and propose an algorithm for conversion between measurement systems.Methods
We used 120 retinal photographs to evaluate the agreement between three commonly used software (Retinal Analysis [RA], Integrative Vessel Analysis [IVAN], and Singapore I Vessel Assessment [SIVA]). Bland-Altman plots were used to evaluate agreement of retinal arteriolar (central retinal artery equivalent, CRAE) and venular (central retinal vein equivalent, CRVE) calibers. Pearson's correlation was used to assess the associations between systemic factors and retinal vessel calibers, and Z-test was used to compare the strength of the correlation coefficients across the three software systems. An algorithm was created to convert measurements, with paired t-test performed to evaluate the differences between SIVA-measured retinal calibers and SIVA-approximates converted from RA- and IVAN-measurements using the algorithm.Results
Differences between SIVA- and RA-measured calibers (CRAE: mean difference [MD] = -21.8 ?m, 95% limits of agreement [LOA], -47.3 to 3.7 ?m; CRVE: MD = -7.7 ?m, 95% LOA, -28.0 to 12.6 ?m), SIVA- and IVAN-measured calibers (CRAE: MD = -6.7 ?m, 95% LOA, -23.8 to 10.4 ?m; CRVE: MD = -18.2 ?m 95% LOA, -36.7 to 0.4 ?m) were large. However, the strength of correlations between systemic factors with SIVA-measured retinal calibers was not significantly different to that measured using RA and IVAN (P ? 0.332). SIVA-approximates converted from RA and IVAN measurements using the proposed algorithm was not significantly different from SIVA-measured calibers (P ? 0.20).Conclusion
Absolute measurements of retinal vessel calibers vary between three common software systems but associations with systemic factors were similar.Translational relevance
The proposed algorithm allowed conversions of RA and IVAN measurements to SIVA-approximates. This conversion is important for future data pooling and establishment of normative values for retinal vascular caliber measurements.
SUBMITTER: Yip W
PROVIDER: S-EPMC5063055 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Yip WanFen W Tham Yih Chung YC Hsu Wynne W Lee Mong Li ML Klein Ronald R Klein Barbara B Ikram Mohammad Kamran MK Wong Tien Yin TY Cheung Carol Yim-Lui CY
Translational vision science & technology 20161012 5
<h4>Purpose</h4>To compare three commonly used retinal vessel caliber measurement software systems, and propose an algorithm for conversion between measurement systems.<h4>Methods</h4>We used 120 retinal photographs to evaluate the agreement between three commonly used software (Retinal Analysis [RA], Integrative Vessel Analysis [IVAN], and Singapore I Vessel Assessment [SIVA]). Bland-Altman plots were used to evaluate agreement of retinal arteriolar (central retinal artery equivalent, CRAE) and ...[more]