Comprehensive functional analysis of the tousled-like kinase 2 frequently amplified in aggressive luminal breast cancers.
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ABSTRACT:
SUBMITTER: Kim JA
PROVIDER: S-EPMC5064015 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
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Comprehensive functional analysis of the tousled-like kinase 2 frequently amplified in aggressive luminal breast cancers.
Kim Jin-Ah JA Tan Ying Y Wang Xian X Cao Xixi X Veeraraghavan Jamunarani J Liang Yulong Y Edwards Dean P DP Huang Shixia S Pan Xuewen X Li Kaiyi K Schiff Rachel R Wang Xiao-Song XS
Nature communications 20161003
More aggressive and therapy-resistant oestrogen receptor (ER)-positive breast cancers remain a great clinical challenge. Here our integrative genomic analysis identifies tousled-like kinase 2 (TLK2) as a candidate kinase target frequently amplified in ∼10.5% of ER-positive breast tumours. The resulting overexpression of TLK2 is more significant in aggressive and advanced tumours, and correlates with worse clinical outcome regardless of endocrine therapy. Ectopic expression of TLK2 leads to enhan ...[more]
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