Functional cooperation between co-amplified genes promotes aggressive phenotypes of HER2-positive breast cancer.
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ABSTRACT:
SUBMITTER: Yang Y
PROVIDER: S-EPMC8050805 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
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Functional cooperation between co-amplified genes promotes aggressive phenotypes of HER2-positive breast cancer.
Yang Yongguang Y Leonard Marissa M Luo Zhenhua Z Yeo Syn S Bick Gregory G Hao Mingang M Cai Chunmiao C Charif Mahmoud M Wang Jiang J Guan Jun-Lin JL Lower Elyse E EE Zhang Xiaoting X
Cell reports 20210301 10
MED1 (mediator subunit 1) co-amplifies with HER2, but its role in HER2-driven mammary tumorigenesis is still unknown. Here, we generate MED1 mammary-specific overexpression mice and cross them with mouse mammary tumor virus (MMTV)-HER2 mice. We observe significantly promoted onset, growth, metastasis, and multiplicity of HER2 tumors by MED1 overexpression. Further studies reveal critical roles for MED1 in epithelial-mesenchymal transition, cancer stem cell formation, and response to anti-HER2 th ...[more]
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