Ontology highlight
ABSTRACT:
SUBMITTER: Vannini N
PROVIDER: S-EPMC5064016 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Vannini Nicola N Girotra Mukul M Naveiras Olaia O Nikitin Gennady G Campos Vasco V Giger Sonja S Roch Aline A Auwerx Johan J Lutolf Matthias P MP
Nature communications 20161012
Haematopoietic stem cells (HSCs) differ from their committed progeny by relying primarily on anaerobic glycolysis rather than mitochondrial oxidative phosphorylation for energy production. However, whether this change in the metabolic program is the cause or the consequence of the unique function of HSCs remains unknown. Here we show that enforced modulation of energy metabolism impacts HSC self-renewal. Lowering the mitochondrial activity of HSCs by chemically uncoupling the electron transport ...[more]