Ontology highlight
ABSTRACT:
SUBMITTER: Pouget C
PROVIDER: S-EPMC4374634 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Nature communications 20141127
Haematopoietic stem cells (HSCs) are produced during embryogenesis from the floor of the dorsal aorta. The localization of HSCs is dependent on the presence of instructive signals on the ventral side of the vessel. The nature of the extrinsic molecular signals that control the aortic haematopoietic niche is currently poorly understood. Here we demonstrate a novel requirement for FGF signalling in the specification of aortic haemogenic endothelium. Our results demonstrate that FGF signalling norm ...[more]