Ontology highlight
ABSTRACT:
SUBMITTER: Novoselova TV
PROVIDER: S-EPMC5064762 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Novoselova T V TV Larder R R Rimmington D D Lelliott C C Wynn E H EH Gorrigan R J RJ Tate P H PH Guasti L L O'Rahilly S S Clark A J L AJ Logan D W DW Coll A P AP Chan L F LF
The Journal of endocrinology 20160422 1
Melanocortin receptor accessory protein 2 (MRAP2) is a transmembrane accessory protein predominantly expressed in the brain. Both global and brain-specific deletion of Mrap2 in mice results in severe obesity. Loss-of-function MRAP2 mutations have also been associated with obesity in humans. Although MRAP2 has been shown to interact with MC4R, a G protein-coupled receptor with an established role in energy homeostasis, appetite regulation and lipid metabolism, the mechanisms through which loss of ...[more]