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Spongosine production by a Vibrio harveyi strain associated with the sponge Tectitethya crypta.

ABSTRACT: Spongosine (1), deoxyspongosine (2), spongothymidine (Ara T) (3), and spongouridine (Ara U) were isolated from the Caribbean sponge Tectitethya crypta and given the general name "spongonucleosides". Spongosine, a methoxyadenosine derivative, has demonstrated a diverse bioactivity profile including anti-inflammatory activity and analgesic and vasodilation properties. Investigations into unusual nucleoside production by T. crypta-associated microorganisms using mass spectrometric techniques have identified a spongosine-producing strain of Vibrio harveyi and several structurally related compounds from multiple strains.

SUBMITTER: Bertin MJ

PROVIDER: S-EPMC5065018 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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Spongosine production by a Vibrio harveyi strain associated with the sponge Tectitethya crypta.

Bertin Matthew J MJ Schwartz Sarah L SL Lee John J Korobeynikov Anton A Dorrestein Pieter C PC Gerwick Lena L Gerwick William H WH

Journal of natural products 20150210 3

Spongosine (1), deoxyspongosine (2), spongothymidine (Ara T) (3), and spongouridine (Ara U) were isolated from the Caribbean sponge Tectitethya crypta and given the general name "spongonucleosides". Spongosine, a methoxyadenosine derivative, has demonstrated a diverse bioactivity profile including anti-inflammatory activity and analgesic and vasodilation properties. Investigations into unusual nucleoside production by T. crypta-associated microorganisms using mass spectrometric techniques have i ...[more]

PMID: 25668560

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