Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC5065142 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Zhang Yani Y Wang Yingjie Y Zuo Qisheng Q Wang Xiaoyan X Li Dong D Tang Beibei B Li Bichun B
PloS one 20161014 10
Several inducers have been used to differentiate embryonic stem cells (ESCs) into male germ cells but the induction process has been inefficient. To solve the problem of low efficiency of inducer for ESCs differentiation into male germ cells, all-trans retinoic acid (ATRA), Am80(the retinoic acid receptor agonist), and estradiol (E2) was used to induce ESCs to differentiate into male germ cells in vitro. ESCs were cultured in media containing ATRA, Am80, or E2 respectively which can differentiat ...[more]