Ontology highlight
ABSTRACT:
SUBMITTER: Polejaeva IA
PROVIDER: S-EPMC5065395 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Polejaeva Irina A IA Ranjan Ravi R Davies Christopher J CJ Regouski Misha M Hall Justin J Olsen Aaron L AL Meng Qinggang Q Rutigliano Heloisa M HM Dosdall Derek J DJ Angel Nathan A NA Sachse Frank B FB Seidel Thomas T Thomas Aaron J AJ Stott Rusty R Panter Kip E KE Lee Pamela M PM Van Wettere Arnaud J AJ Stevens John R JR Wang Zhongde Z MacLeod Rob S RS Marrouche Nassir F NF White Kenneth L KL
Journal of cardiovascular electrophysiology 20160830 10
<h4>Introduction</h4>Large animal models of progressive atrial fibrosis would provide an attractive platform to study relationship between structural and electrical remodeling in atrial fibrillation (AF). Here we established a new transgenic goat model of AF with cardiac specific overexpression of TGF-β1 and investigated the changes in the cardiac structure and function leading to AF.<h4>Methods and results</h4>Transgenic goats with cardiac specific overexpression of constitutively active TGF-β1 ...[more]