Ontology highlight
ABSTRACT:
SUBMITTER: Hung WS
PROVIDER: S-EPMC5066213 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Hung Wei-Shan WS Ling Pin P Cheng Ju-Chien JC Chang Shy-Shin SS Tseng Ching-Ping CP
Scientific reports 20161017
Toll-like receptor 4 (TLR4) plays a pivotal role in the host response to lipopolysaccharide (LPS), a major cell wall component of Gram-negative bacteria. Here, we elucidated whether the endocytic adaptor protein Disabled-2 (Dab2), which is abundantly expressed in macrophages, plays a role in LPS-stimulated TLR4 signaling and trafficking. Molecular analysis and transcriptome profiling of RAW264.7 macrophage-like cells expressing short-hairpin RNA of Dab2 revealed that Dab2 regulated the TLR4/TRIF ...[more]