Ontology highlight
ABSTRACT:
SUBMITTER: Zhu L
PROVIDER: S-EPMC5067024 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Zhu Liqin L Finkelstein David D Gao Culian C Shi Lei L Wang Yongdong Y López-Terrada Dolores D Wang Kasper K Utley Sarah S Pounds Stanley S Neale Geoffrey G Ellison David D Onar-Thomas Arzu A Gilbertson Richard James RJ
Cell 20160801 5
Cancers are distributed unevenly across the body, but the importance of cell intrinsic factors such as stem cell function in determining organ cancer risk is unknown. Therefore, we used Cre-recombination of conditional lineage tracing, oncogene, and tumor suppressor alleles to define populations of stem and non-stem cells in mouse organs and test their life-long susceptibility to tumorigenesis. We show that tumor incidence is determined by the life-long generative capacity of mutated cells. This ...[more]