Ontology highlight
ABSTRACT:
SUBMITTER: Kantamneni H
PROVIDER: S-EPMC5844578 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Kantamneni Harini H Zevon Margot M Donzanti Michael J MJ Zhao Xinyu X Sheng Yang Y Barkund Shravani R SR McCabe Lucas H LH Banach-Petrosky Whitney W Higgins Laura M LM Ganesan Shridar S Riman Richard E RE Roth Charles M CM Tan Mei-Chee MC Pierce Mark C MC Ganapathy Vidya V Moghe Prabhas V PV
Nature biomedical engineering 20171212
The identification and molecular profiling of early metastases remains a major challenge in cancer diagnostics and therapy. Most in vivo imaging methods fail to detect small cancerous lesions, a problem that is compounded by the distinct physical and biological barriers associated with different metastatic niches. Here, we show that intravenously injected rare-earth-doped albumin-encapsulated nanoparticles emitting short-wave infrared light (SWIR) can detect targeted metastatic lesions in vivo, ...[more]