Ontology highlight
ABSTRACT:
SUBMITTER: Koyanagi S
PROVIDER: S-EPMC5067584 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Nature communications 20161014
Diurnal variations in pain hypersensitivity are common in chronic pain disorders, but the underlying mechanisms are enigmatic. Here, we report that mechanical pain hypersensitivity in sciatic nerve-injured mice shows pronounced diurnal alterations, which critically depend on diurnal variations in glucocorticoids from the adrenal glands. Diurnal enhancement of pain hypersensitivity is mediated by glucocorticoid-induced enhancement of the extracellular release of ATP in the spinal cord, which stim ...[more]