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Catechin tuned magnetism of Gd-doped orthovanadate through morphology as T₁-T₂ MRI contrast agents.

ABSTRACT: Tetragonal (t)-LaVO₄ has turned out to be a potential host for luminescent materials. Synthesis of t-LaVO₄ till date has been based on chelating effect of EDTA making it not ideal for bioimaging applications. An alternative was proposed by us through the use of catechin. In recent times there is interest for new MRI contrast agents that can through appropriate doping function both as MRI contrast and optical/upconversion materials. It is generally believed that under appropriate doping, t-LaVO₄ would be a better upconversion material than monoclinic (m)-LaVO₄. Based on these postulations, this work explores the use of gadolinium doped t-LaVO₄ as an MRI contrast agent. From literature, gadolinium oxide is a good T₁ contrast agent. Through this work, using catechin as a template for the synthesis of Gd doped t-LaVO₄, we demonstrate the possible use as a T₁ contrast agent. Interestingly, as the catechin concentration changes, morphology changes from nanorods to square nanoplates and spheres. In this process, a switch from T₁ to T₂ contrast agent was also observed. Under optimal concentration of catechin, with a rod shaped Gd doped t-LaVO₄ an r₂/r₁ value of 21.30 was observed. Similarly, with a spherical shape had an r₂/r₁ value of 1.48 was observed.

SUBMITTER: Vairapperumal T

PROVIDER: S-EPMC5067596 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature

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Catechin tuned magnetism of Gd-doped orthovanadate through morphology as T1-T2 MRI contrast agents.

Vairapperumal Tamilmani T Saraswathy Ariya A Ramapurath Jayasree S JS Kalarical Janardhanan Sreeram S Balachandran Unni Nair N

Scientific reports 20161018

Tetragonal (t)-LaVO4 has turned out to be a potential host for luminescent materials. Synthesis of t-LaVO4 till date has been based on chelating effect of EDTA making it not ideal for bioimaging applications. An alternative was proposed by us through the use of catechin. In recent times there is interest for new MRI contrast agents that can through appropriate doping function both as MRI contrast and optical/upconversion materials. It is generally believed that under approp ...[more]

PMID: 27752038

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Project description:A linear polyamidoamine (PAA) named BAC-EDDS, containing metal chelating repeat units composed of two tert-amines and four carboxylic groups, has been prepared by the aza-Michael polyaddition of ethylendiaminodisuccinic (EDDS) with 2,2-bis(acrylamido)acetic acid (BAC). It was characterized by size exclusion chromatography (SEC), FTIR, UV-Vis and NMR spectroscopies. The pKa values of the ionizable groups of the repeat unit were estimated by potentiometric titration, using a purposely synthesized molecular ligand (Agly-EDDS) mimicking the structure of the BAC-EDDS repeat unit. Dynamic light scattering (DLS) and ζ-potential analyses revealed the propensity of BAC-EDDS to form stable nanoaggregates with a diameter of approximately 150 nm at pH 5 and a net negative charge at physiological pH, in line with an isoelectric point <2. BAC-EDDS stably chelated Gd (III) ions with a molar ratio of 0.5:1 Gd (III)/repeat unit. The stability constant of the molecular model Gd-Agly-EDDS (log K = 17.43) was determined as well, by simulating the potentiometric titration through the use of Hyperquad software. In order to comprehend the efficiency of Gd-BAC-EDDS in contrasting magnetic resonance images, the nuclear longitudinal (r1) and transverse (r2) relaxivities as a function of the externally applied static magnetic field were investigated and compared to the ones of commercial contrast agents. Furthermore, a model derived from the Solomon-Bloembergen-Morgan theory for the field dependence of the NMR relaxivity curves was applied and allowed us to evaluate the rotational correlation time of the complex (τ = 0.66 ns). This relatively high value is due to the dimensions of Gd-BAC-EDDS, and the associated rotational motion causes a peak in the longitudinal relaxivity at ca. 75 MHz, which is close to the frequencies used in clinics. The good performances of Gd-BAC-EDDS as a contrast agent were also confirmed through in vitro magnetic resonance imaging experiments with a 0.2 T magnetic field.

Dataset Information

Catechin tuned magnetism of Gd-doped orthovanadate through morphology as T₁-T₂ MRI contrast agents.

Publications

Catechin tuned magnetism of Gd-doped orthovanadate through morphology as T<sub>1</sub>-T<sub>2</sub> MRI contrast agents.

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