Ontology highlight
ABSTRACT:
SUBMITTER: Fogel GB
PROVIDER: S-EPMC506801 | biostudies-literature | 2004
REPOSITORIES: biostudies-literature
Fogel Gary B GB Weekes Dana G DG Varga Gabor G Dow Ernst R ER Harlow Harry B HB Onyia Jude E JE Su Chen C
Nucleic acids research 20040720 13
Transcription factors are key regulatory elements that control gene expression. Recognition of transcription factor binding site (TFBS) motifs in the upstream region of coexpressed genes is therefore critical towards a true understanding of the regulations of gene expression. The task of discovering eukaryotic TFBSs remains a challenging problem. Here, we demonstrate that evolutionary computation can be used to search for TFBSs in upstream regions of genes known to be coexpressed. Evolutionary c ...[more]