Ontology highlight
ABSTRACT:
SUBMITTER: Bambico FR
PROVIDER: S-EPMC5068759 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Bambico F R FR Bregman T T Diwan M M Li J J Darvish-Ghane S S Li Z Z Laver B B Amorim B O BO Covolan L L Nobrega J N JN Hamani C C
Translational psychiatry 20151103
Chronic ventromedial prefrontal cortex (vmPFC) deep brain stimulation (DBS) improves depressive-like behaviour in rats via serotonergic and neurotrophic-related mechanisms. We hypothesise that, in addition to these substrates, DBS-induced increases in hippocampal neurogenesis may also be involved. Our results show that stress-induced behavioural deficits in the sucrose preference test, forced swim test, novelty-suppressed feeding test (NSFT) and elevated plus maze were countered by chronic vmPFC ...[more]