Unknown

Dataset Information

0

MAVS-dependent host species range and pathogenicity of human hepatitis A virus.


ABSTRACT: Hepatotropic viruses are important causes of human disease, but the intrahepatic immune response to hepatitis viruses is poorly understood because of a lack of tractable small- animal models. We describe a murine model of hepatitis A virus (HAV) infection that recapitulates critical features of type A hepatitis in humans. We demonstrate that the capacity of HAV to evade MAVS-mediated type I interferon responses defines its host species range. HAV-induced liver injury was associated with interferon-independent intrinsic hepatocellular apoptosis and hepatic inflammation that unexpectedly resulted from MAVS and IRF3/7 signaling. This murine model thus reveals a previously undefined link between innate immune responses to virus infection and acute liver injury, providing a new paradigm for viral pathogenesis in the liver.

SUBMITTER: Hirai-Yuki A 

PROVIDER: S-EPMC5068972 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

altmetric image

Publications


Hepatotropic viruses are important causes of human disease, but the intrahepatic immune response to hepatitis viruses is poorly understood because of a lack of tractable small- animal models. We describe a murine model of hepatitis A virus (HAV) infection that recapitulates critical features of type A hepatitis in humans. We demonstrate that the capacity of HAV to evade MAVS-mediated type I interferon responses defines its host species range. HAV-induced liver injury was associated with interfer  ...[more]

Similar Datasets

| S-EPMC6925338 | biostudies-literature
| S-EPMC5101358 | biostudies-literature
| S-EPMC140978 | biostudies-literature
| S-EPMC5893559 | biostudies-literature
| S-EPMC3297057 | biostudies-literature
2016-12-31 | GSE84188 | GEO
| S-EPMC4984625 | biostudies-literature
| S-EPMC6510530 | biostudies-literature
| S-EPMC6232144 | biostudies-literature
| S-EPMC296074 | biostudies-literature