MAVS-dependent host species range and pathogenicity of human hepatitis A virus.
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ABSTRACT:
SUBMITTER: Hirai-Yuki A
PROVIDER: S-EPMC5068972 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Publications
MAVS-dependent host species range and pathogenicity of human hepatitis A virus.
Hirai-Yuki Asuka A Hensley Lucinda L McGivern David R DR González-López Olga O Das Anshuman A Das Anshuman A Feng Hui H Sun Lu L Wilson Justin E JE Hu Fengyu F Feng Zongdi Z Lovell William W Misumi Ichiro I Ting Jenny P-Y JP Montgomery Stephanie S Cullen John J Whitmire Jason K JK Lemon Stanley M SM
Science (New York, N.Y.) 20160915 6307
Hepatotropic viruses are important causes of human disease, but the intrahepatic immune response to hepatitis viruses is poorly understood because of a lack of tractable small- animal models. We describe a murine model of hepatitis A virus (HAV) infection that recapitulates critical features of type A hepatitis in humans. We demonstrate that the capacity of HAV to evade MAVS-mediated type I interferon responses defines its host species range. HAV-induced liver injury was associated with interfer ...[more]
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