Ontology highlight
ABSTRACT:
SUBMITTER: Minster RL
PROVIDER: S-EPMC5069069 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Nature genetics 20160725 9
Samoans are a unique founder population with a high prevalence of obesity, making them well suited for identifying new genetic contributors to obesity. We conducted a genome-wide association study (GWAS) in 3,072 Samoans, discovered a variant, rs12513649, strongly associated with body mass index (BMI) (P = 5.3 × 10(-14)), and replicated the association in 2,102 additional Samoans (P = 1.2 × 10(-9)). Targeted sequencing identified a strongly associated missense variant, rs373863828 (p.Arg457Gln), ...[more]