Dataset Information

DNA methylation variant, B-vitamins intake and longitudinal change in body mass index.

ABSTRACT:

Background

Growing evidence has implicated DNA methylation (DNAm) in the regulation of body adiposity; a recent epigenome-wide association study (EWAS) identified a genetic variant determining DNAm at the SREBF1 gene that affected body mass index (BMI).

Objective

In the present study, we tested interactions between DNAm variant rs752579 and methylation metabolism-related B-vitamins (folate, vitamin B₂, vitamin B₆, and vitamin B₁₂) on longitudinal change in BMI in the Women's Health Initiative Memory Study (WHIMS).

Design

A total of 5687 white women aged 65-79 from WHIMS with genotyping data on SNP rs752579 were included in the analysis. B-vitamins intakes were estimated by a self-report semi-quantitative food frequency questionnaire. BMI was measured at baseline and 6-year follow-up.

Result

We found significant interactions between the SREBF1 rs752579 genotype and intake of food source B-vitamins on 6-year change in BMI (p interaction <0.01 for all). BMI changes (kg/m²) per DNAm-increasing (C) allele were -0.29, 0.06, and 0.11 within subgroups of increasing tertiles of food source folate intake; and the corresponding BMI changes (kg/m²) were -0.25, -0.01, and 0.15 for vitamin B₂ intake; -0.17, -0.16, and 0.21 for vitamin B₆ intake; and -0.12, -0.23, and 0.26 for vitamin B₁₂ intake, respectively. Similar gene-diet interaction patterns were observed on the change in body weight.

Conclusions

Our data suggest that habitual intake of food source B-vitamins may modify the effect of DNAm-related variant on long-term adiposity change.

SUBMITTER: Li X

PROVIDER: S-EPMC8221450 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Publications

DNA methylation variant, B-vitamins intake and longitudinal change in body mass index.

Li Xiang X Wang Tiange T Zhao Min M Huang Tao T Sun Dianjianyi D Han Liyuan L Nisa Hoirun H Shang Xiaoyun X Heianza Yoriko Y Qi Lu L

International journal of obesity (2005) 20180517 3

<h4>Background</h4>Growing evidence has implicated DNA methylation (DNAm) in the regulation of body adiposity; a recent epigenome-wide association study (EWAS) identified a genetic variant determining DNAm at the SREBF1 gene that affected body mass index (BMI).<h4>Objective</h4>In the present study, we tested interactions between DNAm variant rs752579 and methylation metabolism-related B-vitamins (folate, vitamin B<sub>2</sub>, vitamin B<sub>6</sub>, and vitamin B<sub>12</sub>) on longitudinal c ...[more]

PMID: 29777237

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Project description:ImportanceThe incidence of ischemic stroke among young adults is rising and is potentially due to an increase in stroke risk factors occurring at younger ages, such as obesity.ObjectivesTo investigate whether childhood body mass index (BMI) and change in BMI are associated with adult ischemic stroke and to assess whether the associations are age dependent or influenced by birth weight.Design, setting, and participantsThis investigation was a population-based cohort study of schoolchildren born from 1930 to 1987, with follow-up through national health registers from 1977 to 2012 in Denmark. Participants were 307 677 individuals (8899 ischemic stroke cases) with measured weight and height at ages 7 to 13 years. The dates of the analysis were September 1, 2015, to May 27, 2016.Main outcomes and measuresChildhood BMI, change in BMI, and birth weight. Ischemic stroke events were divided into early (≤55 years) or late (>55 years) age at diagnosis.ResultsThe study cohort comprised 307 677 participants (approximately 49% female and 51% male). During the study period, 3529 women and 5370 men experienced an ischemic stroke. At all ages from 7 to 13 years, an above-average BMI z score was positively associated with early ischemic stroke. At age 13 years, a BMI z score of 1 was associated with hazard ratios (HRs) of 1.26 (95% CI, 1.11-1.43) in women and 1.21 (95% CI, 1.10-1.33) in men. No significant associations were found for below-average BMI z scores. Among children with above-average BMI z scores at age 7 years, a score increase of 0.5 from ages 7 to 13 years was positively associated with early ischemic stroke in women (HR, 1.10; 95% CI, 1.01-1.20) and in men (HR, 1.08; 95% CI, 1.00-1.16). Similarly, among children with below-average BMI z scores at age 7 years, a score increase of 0.5 from ages 7 to 13 years was positively associated with early ischemic stroke in women (HR, 1.14; 95% CI, 1.06-1.23) and in men (HR, 1.10; 95% CI, 1.04-1.18). Adjusting for birth weight minimally affected the associations.Conclusions and relevanceIndependent of birth weight, above-average childhood BMI and increases in BMI during childhood are positively associated with early adult ischemic stroke. To avoid the occurrence of early ischemic stroke associated with childhood overweight and obesity, these results suggest that all children should be helped to attain and maintain healthy weights.

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Dataset Information

DNA methylation variant, B-vitamins intake and longitudinal change in body mass index.

Background

Objective

Design

Result

Conclusions

Publications

DNA methylation variant, B-vitamins intake and longitudinal change in body mass index.

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