Ontology highlight
ABSTRACT:
SUBMITTER: Wen J
PROVIDER: S-EPMC5069081 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Wen J J Lee J J Malhotra A A Nahta R R Arnold A R AR Buss M C MC Brown B D BD Maier C C Kenney A M AM Remke M M Ramaswamy V V Taylor M D MD Castellino R C RC
Oncogene 20160418 42
High-level amplification of the protein phosphatase PPM1D (WIP1) is present in a subset of medulloblastomas (MBs) that have an expression profile consistent with active Sonic Hedgehog (SHH) signaling. We found that WIP1 overexpression increased expression of Shh target genes and cell proliferation in response to Shh stimulation in NIH3T3 and cerebellar granule neuron precursor cells in a p53-independent manner. Thus, we developed a mouse in which WIP1 is expressed in the developing brain under c ...[more]