Ontology highlight
ABSTRACT:
SUBMITTER: Wijaya J
PROVIDER: S-EPMC7416697 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Wijaya Juwina J Vo BaoHan T BT Liu Jingjing J Xu Beisi B Wu Gang G Wang Yao Y Peng Junmin J Zhang Jin J Janke Laura J LJ Orr Brent A BA Yu Jiyang J Roussel Martine F MF Schuetz John D JD
Cancer research 20200116 7
Mutations in Sonic hedgehog (SHH) signaling promote aberrant proliferation and tumor growth. SHH-medulloblastoma (MB) is among the most frequent brain tumors in children less than 3 years of age. Although key components of the SHH pathway are well-known, we hypothesized that new disease-modifying targets of SHH-MB might be identified from large-scale bioinformatics and systems biology analyses. Using a data-driven systems biology approach, we built a MB-specific interactome. The ATP-binding cass ...[more]