Dataset Information

Yolk-Shell-Structured Aluminum Phenylphosphonate Microspheres with Anionic Core and Cationic Shell.

ABSTRACT: Spherical materials with yolk-shell structure have great potential for a wide range of applications. The main advantage of the yolk-shell geometry is the possibility of introducing different chemical or physical properties within a single particle. Here, a one-step hydrothermal synthesis route for fabricating amphoteric yolk-shell structured aluminum phenylphosphonate microspheres using urea as the precipitant is proposed. The resulting microspheres display 3D sphere-in-sphere architecture with anionic core and cationic shell. The controllable synthesis of aluminum phosphates with various morphologies is also demonstrated. The anionic core and cationic shell of the aluminum phenylphosphonate microspheres provide docking sites for selective adsorption of both cationic methylene blue and anionic binuclear cobalt phthalocyanine ammonium sulphonate. These new adsorbents can be used for simultaneous capture of both cations and anions from a solution, which make them very attractive for various applications such as environmental remediation of contaminated water.

SUBMITTER: Zhang L

PROVIDER: S-EPMC5069564 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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Yolk-Shell-Structured Aluminum Phenylphosphonate Microspheres with Anionic Core and Cationic Shell.

Zhang Liqiu L Qian Kun K Wang Xupeng X Zhang Fan F Shi Xin X Jiang Yijiao Y Liu Shaomin S Jaroniec Mietek M Liu Jian J

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20160225 5

Spherical materials with yolk-shell structure have great potential for a wide range of applications. The main advantage of the yolk-shell geometry is the possibility of introducing different chemical or physical properties within a single particle. Here, a one-step hydrothermal synthesis route for fabricating amphoteric yolk-shell structured aluminum phenylphosphonate microspheres using urea as the precipitant is proposed. The resulting microspheres display 3D sphere-in-sphere architecture with ...[more]

PMID: 27812467

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Project description:Cationic non-viral vectors show great potential to introduce genetic material into cells, due to their ability to transport large amounts of genetic material and their high synthetic versatility. However, designing materials that are effective without showing toxic effects or undergoing non-specific interactions when applied systemically remains a challenge. The introduction of shielding polymers such as polyethylene glycol (PEG) can enhance biocompatibility and circulation time, however, often impairs transfection efficiency. Herein, a multicomponent polymer system is introduced, based on cationic and hydrophobic particles (P(nBMA46-co-MMA47-co-DMAEMA90), (PBMD)) with high delivery performance and a pH-responsive block copolymer (poly((N-acryloylmorpholine)-b-(2-(carboxy)ethyl acrylamide)) (P(NAM72-b-CEAm74), PNC)) as shielding system, with PNAM as alternative to PEG. The pH-sensitive polymer design promotes biocompatibility and excellent stability at extracellular conditions (pH 7.4) and also allows endosomal escape and thus high transfection efficiency under acidic conditions. PNC shielded particles are below 200 nm in diameter and showed stable pDNA complexation. Further, interaction with human erythrocytes at extracellular conditions (pH 7.4) was prevented, while acidic conditions (pH 6) enabled membrane leakage. The particles demonstrate transfection in adherent (HEK293T) as well as difficult-to-transfect suspension cells (K-562), with comparable or superior efficiency compared to commercial linear poly(ethylenimine) (LPEI). Besides, the toxicity of PNC-shielded particles was significantly minimized, in particular in K-562 cells and erythrocytes. In addition, a pilot in vivo experiment on bone marrow blood cells of mice that were injected with PNC-shielded particles, revealed slightly enhanced cell transfection in comparison to naked pDNA. This study demonstrates the applicability of cationic hydrophobic polymers for transfection of adherent and suspension cells in culture as well as in vivo by co-formulation with pH-responsive shielding polymers, without substantially compromising transfection performance.

Dataset Information

Yolk-Shell-Structured Aluminum Phenylphosphonate Microspheres with Anionic Core and Cationic Shell.

Publications

Yolk-Shell-Structured Aluminum Phenylphosphonate Microspheres with Anionic Core and Cationic Shell.

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