Ontology highlight
ABSTRACT:
SUBMITTER: Crofford LJ
PROVIDER: S-EPMC5070917 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Crofford Leslie J LJ Nyhoff Lindsay E LE Sheehan Jonathan H JH Kendall Peggy L PL
Expert review of clinical immunology 20160304 7
Bruton's tyrosine kinase (BTK) mediates B cell signaling and is also present in innate immune cells but not T cells. BTK propagates B cell receptor (BCR) responses to antigen-engagement as well as to stimulation via CD40, toll-like receptors (TLRs), Fc receptors (FCRs) and chemokine receptors. Importantly, BTK can modulate signaling, acting as a "rheostat" rather than an "on-off" switch; thus, overexpression leads to autoimmunity while decreased levels improve autoimmune disease outcomes. Autore ...[more]