Unknown

Dataset Information

0

The role of Bruton's tyrosine kinase in autoimmunity and implications for therapy.


ABSTRACT: Bruton's tyrosine kinase (BTK) mediates B cell signaling and is also present in innate immune cells but not T cells. BTK propagates B cell receptor (BCR) responses to antigen-engagement as well as to stimulation via CD40, toll-like receptors (TLRs), Fc receptors (FCRs) and chemokine receptors. Importantly, BTK can modulate signaling, acting as a "rheostat" rather than an "on-off" switch; thus, overexpression leads to autoimmunity while decreased levels improve autoimmune disease outcomes. Autoreactive B cells depend upon BTK for survival to a greater degree than normal B cells, reflected as loss of autoantibodies with maintenance of total antibody levels when BTK is absent. This review describes contributions of BTK to immune tolerance, including studies testing BTK-inhibitors for treatment of autoimmune diseases.

SUBMITTER: Crofford LJ 

PROVIDER: S-EPMC5070917 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

altmetric image

Publications

The role of Bruton's tyrosine kinase in autoimmunity and implications for therapy.

Crofford Leslie J LJ   Nyhoff Lindsay E LE   Sheehan Jonathan H JH   Kendall Peggy L PL  

Expert review of clinical immunology 20160304 7


Bruton's tyrosine kinase (BTK) mediates B cell signaling and is also present in innate immune cells but not T cells. BTK propagates B cell receptor (BCR) responses to antigen-engagement as well as to stimulation via CD40, toll-like receptors (TLRs), Fc receptors (FCRs) and chemokine receptors. Importantly, BTK can modulate signaling, acting as a "rheostat" rather than an "on-off" switch; thus, overexpression leads to autoimmunity while decreased levels improve autoimmune disease outcomes. Autore  ...[more]

Similar Datasets

| S-EPMC5817726 | biostudies-literature
| S-EPMC6738557 | biostudies-literature
| S-EPMC8261291 | biostudies-literature
| S-EPMC8491186 | biostudies-literature
| S-EPMC7970705 | biostudies-literature
| S-EPMC3985139 | biostudies-literature
| S-EPMC8198777 | biostudies-literature
| S-EPMC7685672 | biostudies-literature
| S-EPMC9607648 | biostudies-literature
| S-EPMC3594038 | biostudies-literature