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Genome-wide analyses of aggressiveness in attention-deficit hyperactivity disorder.

ABSTRACT: Aggressiveness is a behavioral trait that has the potential to be harmful to individuals and society. With an estimated heritability of about 40%, genetics is important in its development. We performed an exploratory genome-wide association (GWA) analysis of childhood aggressiveness in attention deficit hyperactivity disorder (ADHD) to gain insight into the underlying biological processes associated with this trait. Our primary sample consisted of 1,060 adult ADHD patients (aADHD). To further explore the genetic architecture of childhood aggressiveness, we performed enrichment analyses of suggestive genome-wide associations observed in aADHD among GWA signals of dimensions of oppositionality (defiant/vindictive and irritable dimensions) in childhood ADHD (cADHD). No single polymorphism reached genome-wide significance (P?

SUBMITTER: Brevik EJ 

PROVIDER: S-EPMC5071721 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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Genome-wide analyses of aggressiveness in attention-deficit hyperactivity disorder.

Brevik Erlend J EJ   van Donkelaar Marjolein M J MM   Weber Heike H   Sánchez-Mora Cristina C   Jacob Christian C   Rivero Olga O   Kittel-Schneider Sarah S   Garcia-Martínez Iris I   Aebi Marcel M   van Hulzen Kimm K   Cormand Bru B   Ramos-Quiroga Josep A JA   Lesch Klaus-Peter KP   Reif Andreas A   Ribasés Marta M   Franke Barbara B   Posserud Maj-Britt MB   Johansson Stefan S   Lundervold Astri J AJ   Haavik Jan J   Zayats Tetyana T  

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 20160329 5

Aggressiveness is a behavioral trait that has the potential to be harmful to individuals and society. With an estimated heritability of about 40%, genetics is important in its development. We performed an exploratory genome-wide association (GWA) analysis of childhood aggressiveness in attention deficit hyperactivity disorder (ADHD) to gain insight into the underlying biological processes associated with this trait. Our primary sample consisted of 1,060 adult ADHD patients (aADHD). To further ex  ...[more]

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