Ontology highlight
ABSTRACT:
SUBMITTER: Fieulaine S
PROVIDER: S-EPMC5071857 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Fieulaine Sonia S Alves de Sousa Rodolphe R Maigre Laure L Hamiche Karim K Alimi Mickael M Bolla Jean-Michel JM Taleb Abbass A Denis Alexis A Pagès Jean-Marie JM Artaud Isabelle I Meinnel Thierry T Giglione Carmela C
Scientific reports 20161020
Peptide deformylase (PDF) is considered an excellent target to develop antibiotics. We have performed an extensive characterization of a new PDF from the pathogen Streptococcus agalactiae, showing properties similar to other known PDFs. S. agalactiae PDF could be used as PDF prototype as it allowed to get complete sets of 3-dimensional, biophysical and kinetic data with virtually any inhibitor compound. Structure-activity relationship analysis with this single reference system allowed us to reve ...[more]