Ontology highlight
ABSTRACT:
SUBMITTER: Bailey P
PROVIDER: S-EPMC5071896 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Bailey Peter P Chang David K DK Forget Marie-Andrée MA Lucas Francis A San FA Alvarez Hector A HA Haymaker Cara C Chattopadhyay Chandrani C Kim Sun-Hee SH Ekmekcioglu Suhendan S Grimm Elizabeth A EA Biankin Andrew V AV Hwu Patrick P Maitra Anirban A Roszik Jason J
Scientific reports 20161020
Immunotherapy approaches for pancreatic ductal adenocarcinoma (PDAC) have met with limited success. It has been postulated that a low mutation load may lead to a paucity of T cells within the tumor microenvironment (TME). However, it is also possible that while neoantigens are present, an effective immune response cannot be generated due to an immune suppressive TME. To discern whether targetable neoantigens exist in PDAC, we performed a comprehensive study using genomic profiles of 221 PDAC cas ...[more]