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Rational combinations of immunotherapy for pancreatic ductal adenocarcinoma.

ABSTRACT: The complex interaction between the immune system, the tumor and the microenvironment in pancreatic ductal adenocarcinoma (PDA) leads to the resistance of PDA to immunotherapy. To overcome this resistance, combination immunotherapy is being proposed. However, rational combinations that target multiple aspects of the complex anti-tumor immune response are warranted. Novel clinical trials will investigate and optimize the combination immunotherapy for PDA.

SUBMITTER: Blair AB

PROVIDER: S-EPMC6178804 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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Rational combinations of immunotherapy for pancreatic ductal adenocarcinoma.

Blair Alex B AB Zheng Lei L

Chinese clinical oncology 20170601 3

The complex interaction between the immune system, the tumor and the microenvironment in pancreatic ductal adenocarcinoma (PDA) leads to the resistance of PDA to immunotherapy. To overcome this resistance, combination immunotherapy is being proposed. However, rational combinations that target multiple aspects of the complex anti-tumor immune response are warranted. Novel clinical trials will investigate and optimize the combination immunotherapy for PDA. ...[more]

PMID: 28705008

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