Ontology highlight
ABSTRACT:
SUBMITTER: Qi Q
PROVIDER: S-EPMC5072604 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Qi Qian Q Cavanagh Mary M MM Le Saux Sabine S Wagar Lisa E LE Mackey Sally S Hu Jinyu J Maecker Holden H Swan Gary E GE Davis Mark M MM Dekker Cornelia L CL Tian Lu L Weyand Cornelia M CM Goronzy Jörg J JJ
PLoS pathogens 20161020 10
Vaccination with attenuated live varicella zoster virus (VZV) can prevent zoster reactivation, but protection is incomplete especially in an older population. To decipher the molecular mechanisms underlying variable vaccine responses, T- and B-cell responses to VZV vaccination were examined in individuals of different ages including identical twin pairs. Contrary to the induction of VZV-specific antibodies, antigen-specific T cell responses were significantly influenced by inherited factors. Dim ...[more]