Ontology highlight
ABSTRACT:
SUBMITTER: Nakano M
PROVIDER: S-EPMC5073111 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Nakano Masako M Witcher Jennifer J Satoi Yoichi Y Goto Taro T
Clinical drug investigation 20161101 11
<h4>Background and objectives</h4>There is a clinical need for a liquid formulation of atomoxetine. We assessed the safety and bioequivalence of an atomoxetine oral solution.<h4>Methods</h4>This was an open-label, randomized, crossover study. Healthy adult male Japanese subjects (n = 42) with a cytochrome P450 2D6 extensive (including intermediate and ultrarapid) metabolizer genotype were administered atomoxetine 50 mg as oral solution and capsules once each, with a washout period >5 days betwee ...[more]